Intractable Rare Dis Res. 2020;9(3):184-186. (DOI: 10.5582/irdr.2020.03025)

An update on microRNAs as potential novel therapeutic targets in testicular germ cell tumors

De Martino M, Esposito F, Chieffi P


Testicular germ cell tumors (TGCTs) are the most frequent solid malignant tumors in men 20- 40 years of age and the most frequent cause of death from solid tumors in this age group. Recent studies have underscored the fact that miRNA deregulation is a feature of carcinogenesis, including TGCT development and progression. MiRNAs are a group of small noncoding RNAs that bind to the 3′-untranslated region (UTR) of the targeted mRNAs, thus causing mRNA degradation or the inhibition of its translation, regulating gene expression in a temporal and tissue-specific manner. However, few miRNAs have been found to play key roles in TGCTs; recently, other miRNAs have been identified, representing novel potential therapeutic targets.

KEYWORDS: HMGA1, microRNA, testicular germ cell tumor (TGCT), seminoma

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